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KMID : 1036720140470020113
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Journal of Nutrition and Health
2014 Volume.47 No. 2 p.113 ~ p.123
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Associations of serum 25(OH)D levels with depression and depressed condition in Korean adults: results from KNHANES 2008-2010
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Koo Sle
Park Kyong
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Abstract
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Purpose: Vitamin D has been known to play an important role in the central nervous system and brain functions in the human body, and cumulative evidence has shown that vitamin D deficiency might be linked with various mental health conditions. Epidemiologic studies have shown that vitamin D deficiency may be associated with higher risk of depression in the US and European populations. However, limited information is available regarding the association between vitamin D status and depression in the Korean population. The objective of this study was to examine the associations between vitamin D levels and prevalence of depression.
Methods: We conducted a cross-sectional analysis using nationally representative data from the 2008-2010 Korean National Health and Nutrition Examination Survey from which serum 25-hydroxyvitamin D concentrations were available. A total of 18,735 adults who had available demographic, dietary, and lifestyle information were included in our analysis. We defined “depression” with a diagnosis by a physician. “Depressed condition” was defined as having feelings of sadness or depression without diagnosis by a physician.
Results: The prev-alence of depression was 1.63% and 5.43% in Korean men and women, respectively; 12.5% of men and 26.1% of women were defined as the group having depressed conditions. In multivariate logistic regression models, no significant associa-tions were observed between vitamin D status and prevalence of depression or depressed conditions in Korean men and women.
Conclusion: We found no association between vitamin D insufficiency and depression/depressed condi-tions in Korean adults. Future large prospective studies and randomized controlled trials are needed to confirm this rela-tionship.
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KEYWORD
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depression, depressed condition, 25-hydroxyvitamin D, Korean adults
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